Drug Induced Ototoxicity

Continuing Education Drug - Induced Ototoxicity

Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss.

Sorry, there is no abstract. Read the first few lines of the text instead! Medicines procured from herbs, animals or the soil have been with humanity since the dawn of civilization. Mostly, we assume, as cures for our ailments, but also to our detriment, as Socrates' hemlock and Shakespeare's 'juice of cursed hebona' attest (although we might argue that the murder of Hamlet's father was not to ...

Calreticulin binds to gentamicin and reduces drug-induced ototoxicity.

Aminoglycosides like gentamicin are among the most commonly used antibiotics in clinical practice and are essential for treating life-threatening tuberculosis and Gram-negative bacterial infections. However, aminoglycosides are also nephrotoxic and ototoxic. Although a number of mechanisms have been proposed, it is still unclear how aminoglycosides induce cell death in auditory sensory epitheli...

Desferioximine induced Ototoxicity in Thalassemic patients

BACKGROUND Thalassemia is a hereditary disorder requiring regular blood transfusion. PURPOSE To determine hearing sensitivity in transfusion-dependent thalassemics who were receiving desferioximine and on oral iron chelation (desferioximine) therapy. METHODS 26 patients with B-thelassemia in the age range of 5-22 years were enrolled in the thalassemia transfusion unit in the Advanced Pediat...

Cisplatin-induced Ototoxicity. Pharmacokinetics, Prediction and Prevention